2024
Burattini M,
Lo Muzio FP, Hu M, Bonalumi F, Rossi S, Pagiatakis C,
Salvarani N, Fassina L, Luciani GB, Miragoli M. Unlocking
cardiac motion: assessing software and machine learning for
single-cell and cardioid kinematic insights. Sci Rep.
2024 Jan 20;14(1):1782. doi: 10.1038/s41598-024-52081-9.
2021-2023
Bonalumi F,
Miragoli M. Invited Perspective: The Silent Threat-Air
Pollution's Link to Arrhythmias. Environ Health Perspect.
2023 Nov;131(11):111301. doi: 10.1289/EHP13720. Epub 2023
Nov 1. PMID: 37909724; PMCID: PMC10619429.
Serio S,
Pagiatakis C, Musolino E, Felicetta A, Carullo P, Laura
Frances J, Papa L, Rozzi G, Salvarani N, Miragoli M, Gornati
R, Bernardini G, Condorelli G, Papait R. Cardiac Aging Is
Promoted by Pseudohypoxia Increasing p300-Induced
Glycolysis. Circ Res. 2023 Sep 29;133(8):687-703.
doi: 10.1161/CIRCRESAHA.123.322676. Epub 2023 Sep 8. PMID:
37681309.
Mendiola Pla
M, Berrettoni S, Lee FH, Rozzi G, Marrano F, Gross RT, Evans
A, Wendell DC, Lezberg P, Burattini M, Paolo Lo Muzio F,
Fassina L, Milano CA, Bang ML, Bowles DE, Miragoli M. Video
analysis of ex vivo beating hearts during preservation on
the TransMedics® organ care system. Front Cardiovasc Med.
2023 Jun 20;10:1216917. doi: 10.3389/fcvm.2023.1216917.
PMID: 37408655.
Rossi S,
Statello R, Pelà G, Leonardi F, Cabassi A, Foresti R, Rozzi
G, Lo Muzio FP, Carnevali L, Sgoifo A, Magnani L, Callegari
S, Pastori P, Tafuni A, Corradi D, Miragoli M, Macchi E.
Age-related increases in cardiac excitability,
refractoriness and impulse conduction favor arrhythmogenesis
in male rats. Pflugers Arch. 2023
Jun;475(6):731-745. doi: 10.1007/s00424-023-02812-0. Epub
2023 Apr 6.
Gerbolés AG,
Galetti M, Rossi S, Lo Muzio FP, Pinelli S, Delmonte N,
Caffarra Malvezzi C, Macaluso C, Miragoli M, Foresti R.
Three-Dimensional Bioprinting of Organoid-Based Scaffolds
(OBST) for Long-Term Nanoparticle Toxicology Investigation.
Int J Mol Sci. 2023 Apr 1;24(7):6595. doi:
10.3390/ijms24076595. PMID: 37047568
Statello R,
Rossi S, Pisani F, Bonzini M, Andreoli R, Martini A,
Puligheddu M, Cocco P, Miragoli M. Nocturnal Heart Rate
Variability Might Help in Predicting Severe Obstructive
Sleep-Disordered Breathing. Biology (Basel). 2023
Mar 31;12(4):533. doi: 10.3390/biology12040533. PMID:
37106734.
Pisani F, Statello R, Pedrazzi G, Miragoli M, Piccolo B, Turco EC. The duration of successive epileptic seizures is monotonically correlated in neonates. Neurophysiol Clin. 2022 Nov;52(6):472-481. doi: 10.1016/j.neucli.2022.10.004. Epub 2022 Nov 10. PMID: 36372645.
Mozzoni P,
Iodice S, Persico N, Ferrari L, Pinelli S, Corradi M, Rossi
S, Miragoli M, Bergamaschi E, Bollati V; INSIDE Consortium
investigators. Maternal
air pollution exposure during the first trimester of pregnancy
and markers of inflammation and endothelial dysfunction. Environ Res . 2022
Sep;212(Pt A):113216. doi:
10.1016/j.envres.2022.113216. Epub 2022 Mar 30.
Fassina L,
Assenza MR, Miragoli M, Isidori AM, Naro F, Barbagallo F. Cell Shortening and Calcium Homeostasis
Analysis in Adult Cardiomyocytes via a New Software Tool. Biomedicines. 2022 Mar
10;10(3):640. doi: 10.3390/biomedicines10030640.
Lagonegro, P.,
Rossi, S., Salvarani, N. ...and Michele Miragoli. Synthetic
recovery of impulse propagation in myocardial infarction via
silicon carbide semiconductive nanowires. Nat Commun
13, 6 (2022). https://doi.org/10.1038/s41467-021-27637-2
Modica J, Di
Mauro V, Barandalla-Sobrados M, Chavez SEP, Carullo P,
Nemska S, Anselmo A, Condorelli G, Iafisco M, Miragoli M,
Catalucci D. Nano-miR-133a Replacement Therapy Blunts
Pressure Overload-Induced Heart Failure. Circulation.
2021 Dec 14;144(24):1973-1976. doi:
10.1161/CIRCULATIONAHA.121.055866. Epub 2021
Lo Muzio FP,
Rozzi G, Rossi S, Luciani GB, Foresti R, Cabassi A, Fassina
L, Miragoli M.Artificial Intelligence Supports
Decision Making during Open-Chest Surgery of Rare
Congenital Heart Defects. J Clin Med . 2021 Nov
16;10(22):5330 doi: 10.3390/jcm10225330.
Statello R,
Carnevali L, Sgoifo A, Miragoli M, Pisani F.. Heart rate
variability in neonatal seizures: Investigation and
implications for management. Neurophysiol Clin. 2021
Nov 10:S0987-7053(21)00094-0. doi:
10.1016/j.neucli.2021.10.002
Achille
Anselmo, Derk Frank, Laura Papa, Chiara
Viviani Anselmi, Elisa Di Pasquale, Marta
Mazzola, Cristina Panico, Francesca
Clemente, Cristiana Soldani, Christina
Pagiatakis, Rabea Hinkel, Ruth Thalmann,
Reiner Kozlik-Feldmann, Michele Miragoli, Pierluigi
Carullo, Marco Vacchiano, Antonio
Chaves-Sanjuan, Nadia Santo, Maria Angela Losi,
Matteo Carlo Ferrari, Annibale Alessandro Puca,
Vincent Christiansen, Hatim Seoudy, Sandra
Freitag-Wolf, Norbert Frey, Astrid Dempfle, Mark
Mercola, Giovanni Esposito, Carlo
Briguori, Christian Kupatt, Gianluigi Condorelli.
Myocardial hypoxic stress mediates functional cardiac
extracellular vesicle release. European Heart Journal,
2021;, ehab247, https://doi.org/10.1093/eurheartj/ehab247.
Rossi S,
Buccarello A, Caffarra Malvezzi C, Pinelli S, Alinovi R,
Guerrero Gerboles A, Rozzi G, Leonardi F, Bollati V, De
Palma G, Lagonegro P, Rossi F, Lottici PP, Poli D, Statello
R, Macchi E, Miragoli M. Exposure to
nanoparticles derived from diesel particulate filter
equipped engine increases vulnerability to arrhythmia in rat
hearts. Environ Pollut. 2021 Apr
20;284:117163. doi: 10.1016/j.envpol.2021.117163.
Lionetti V, Bollini S, Coppini R, Gerbino A, Ghigo A, Iaccarino G, Madonna R, Mangiacapra F, Miragoli M, Moccia F, Munaron L, Pagliaro P, Parenti A, Pasqua T, Penna C, Quaini F, Rocca C, Samaja M, Sartiani L, Soda T, Tocchetti CG, Angelone T. Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development. Pharmacol Res . 2021 Mar 26;168:105581. doi: 10.1016/j.phrs.2021.105581.
Rozzi G, Lo Muzio FP, Fassina L, Rossi S, Statello R, Sandrini C, Laricchiuta M, Faggian G, Miragoli M, Luciani GB. Right ventricular functional recovery depends on timing of pulmonary valve replacement in tetralogy of Fallot: a video kinematic study. Eur J Cardiothorac Surg. 2021 Feb 6:ezab026. doi: 10.1093/ejcts/ezab026
Medvedev R,
Sanchez-Alonso JL, Alvarez-Laviada A, Rossi S, Dries E,
Schorn T, Abdul-Salam VB, Trayanova N, Wojciak-Stothard B,
Miragoli M, Faggian G, Gorelik J. Nanoscale
Study of Calcium Handling Remodeling in Right Ventricular
Cardiomyocytes Following Pulmonary Hypertension.
Hypertension. 2021 Feb;77(2):605-616. doi:
10.1161/HYPERTENSIONAHA.120.14858. Epub 2020 Dec 28.
Medvedev RY,
Sanchez-Alonso JL, Mansfield CA, Judina A, Francis AJ,
Pagiatakis C, Trayanova N, Glukhov AV, Miragoli M, Faggian
G, Gorelik J. Local hyperactivation of
L-type Ca 2+ channels increases spontaneous Ca 2+ release
activity and cellular hypertrophy in right ventricular
myocytes from heart failure rats. Sci Rep. 2021
Mar 1;11(1):4840. doi: 10.1038/s41598-021-84275-w.
Foresti R,
Ghezzi B, Vettori M, Bergonzi L, Attolino S, Rossi S,
Tarabella G, Vurro D, von Zeppelin D, Iannotta S, Zappettini
A, Macaluso GM, Miragoli M, Maggio MG, Costantino C, Selleri
S, Macaluso C. 3D Printed Masks for
Powders and Viruses Safety Protection Using Food Grade
Polymers: Empirical Tests. Polymers (Basel) .
2021 Feb 18;13(4):617. doi: 10.3390/polym13040617.
2019-2020
Caffarra
Malvezzi C, Cabassi A, Miragoli .
M.Mitochondrial mechanosensor in cardiovascular
diseases. Vasc Biol. 2020 Jun
22;2(1):R85-R92. doi: 10.1530/VB-20-0002.
eCollection 2020.
Foresti
R, Rossi S, Pinelli S, Alinovi R, Sciancalepore
C, Delmonte N, Selleri S, Caffarra C, Raposio E,
Macaluso G, Macaluso C, Freyrie A, Miragoli M,
Perini P.. In-vivo
vascular application via ultra-fast bioprinting for
future 5D personalised nanomedicine. Sci Rep. 2020
Feb 21;10(1):3205. doi: 10.1038/s41598-020-60196-y.
Moccia
F, Gerbino A, Lionetti V, Miragoli M, Munaron
LM, Pagliaro P, Pasqua T, Penna C, Rocca C,
Samaja M, Angelone T.COVID-19-associated
cardiovascular morbidity in older adults: a position
paper from the Italian Society of Cardiovascular
Researches. Geroscience. 2020 May 20:1-29. doi:
10.1007/s11357-020-00198-w.
Cattelan
G, Guerrero Gerbolés A, Foresti R, Pramstaller PP,
Rossini A, Miragoli M, Caffarra Malvezzi C. Alginate
Formulations: Current Developments in the Race for
Hydrogel-Based Cardiac Regeneration. Front Bioeng
Biotechnol . 2020 May 8;8:414. doi:
10.3389/fbioe.2020.00414. eCollection 2020.
Miragoli
M, Goldoni M, Demola P, Paterlini A, Li Calzi M, Gioia
MI, Visioli F, Rossi S, Pelà G.Left
ventricular geometry correlates with early repolarization
pattern in adolescent athletes. Scand J Med Sci Sports.
2019 Nov;29(11):1727-1735. doi: 10.1111/sms.13518. Epub 2019
Jul 29.
Schultz
F, Swiatlowska P, Alvarez-Laviada A, Sanchez-Alonso JL,
Song Q, de Vries AAF, Pijnappels DA, Ongstad E, Braga
VMM, Entcheva E, Gourdie RG, Miragoli M, Gorelik J.Cardiomyocyte-myofibroblast
contact dynamism is modulated by connexin-43. FASEB J.
2019 Sep;33(9):10453-10468. doi: 10.1096/fj.201802740RR.
Epub 2019 Jul 5.
Rossi
S, Savi M, Mazzola M, Pinelli S, Alinovi R, Gennaccaro
L, Pagliaro A, Meraviglia V, Galetti M, Lozano-Garcia O,
Rossini A, Frati C, Falco A, Quaini F, Bocchi L, Stilli
D, Lucas S, Goldoni M, Macchi E, Mutti A, Miragoli M#. Subchronic
exposure to titanium dioxide nanoparticles modifies cardiac
structure and performance in spontaneously hypertensive
rats. Part Fibre Toxicol. 2019 Jun 24;16(1):25. doi:
10.1186/s12989-019-0311-7.
Lo
Muzio FP, Rozzi G, Rossi S, Gerbolés AG, Fassina L, Pelà
G, Luciani GB, Miragoli M#. In-situ
optical assessment of rat epicardial kinematic parameters
reveals frequency-dependent mechanic heterogeneity related
to gender. Prog Biophys Mol Biol. 2019 May 21. pii:
S0079-6107(19)30054-9. doi:
10.1016/j.pbiomolbio.2019.05.003. [Epub ahead of print]
Salvarani
N, Crasto S, Miragoli M, Bertero A, Paulis M,
Kunderfranco P, Serio S, Forni A, Lucarelli C, Dal Ferro
M, Larcher V, Sinagra G, Vezzoni P, Murry CE, Faggian G,
Condorelli G, Di Pasquale E. The
K219T-Lamin mutation induces conduction defects through
epigenetic inhibition of SCN5A in human cardiac laminopathy.
Nat Commun. 2019 May 22;10(1):2267. doi:
10.1038/s41467-019-09929-w.
2018
Iodice
S, Hoxha M, Ferrari L, Carbone IF, Anceschi C, Miragoli
M, Pesatori AC, Persico N, Bollati V. Particulate
Air Pollution, Blood Mitochondrial DNA Copy Number, and
Telomere Length in Mothers in the First Trimester of
Pregnancy: Effects on Fetal Growth. Oxid Med Cell
Longev. 2018 Nov 5;2018:5162905. doi:
10.1155/2018/5162905. eCollection 2018.
Marrella
A, Iafisco M, Adamiano A, Rossi S, Aiello M,
Barandalla-Sobrados M, Carullo P, Miragoli M, Tampieri
A, Scaglione S, Catalucci D. A combined
low-frequency electromagnetic and fluidic stimulation for a
controlled drug release from superparamagnetic calcium
phosphate nanoparticles: potential application for
cardiovascular diseases. J R Soc Interface. 2018
Jul;15(144). pii: 20180236. doi: 10.1098/rsif.2018.0236.
Miragoli
M*, Ceriotti P, Iafisco M, Vacchiano M, Salvarani N,
Alogna A, Carullo P, Ramirez-Rodríguez GB, Patrício T,
Esposti LD, Rossi F, Ravanetti F, Pinelli S, Alinovi R,
Erreni M, Rossi S, Condorelli G, Post H, Tampieri A,
Catalucci D. Inhalation of peptide-loaded
nanoparticles improves heart failure. Sci Transl Med.
2018 Jan 17;10(424). pii: eaan6205. doi:
10.1126/scitranslmed.aan6205.
2017
Gesmundo
I*, Miragoli M*, Carullo P, Trovato L, Larcher V, Di
Pasquale E, Brancaccio M, Mazzola M, Villanova T, Sorge
M, Taliano M, Gallo MP, Alloatti G, Penna C, Hare JM,
Ghigo E, Schally AV, Condorelli G, Granata R. Growth
hormone-releasing hormone attenuates cardiac hypertrophy and
improves heart function in pressure overload-induced heart
failure. Proc Natl Acad Sci U S A. 2017 Nov
7;114(45):12033-12038. doi: 10.1073/pnas.1712612114. Epub
2017 Oct 25.
Papait R, Serio S, Pagiatakis C, Rusconi F, Carullo P, Mazzola M, Salvarani N, Miragoli M, Condorelli G. Histone Methyltransferase G9a is Required for Cardiomyocyte Homeostasis and Hypertrophy. Circulation. 2017 Sep 26;136(13):1233-1246
Cabassi
A, Miragoli M*. Altered
Mitochondrial Metabolism and Mechanosensation in the Failing
Heart: Focus on Intracellular Calcium Signaling. Int J Mol Sci. 2017 Jul
10;18(7). pii: E1487. doi: 10.3390/ijms18071487. Review.
PMID: 28698526
Miragoli
M*, Cabassi
A. Mitochondrial Mechanosensor Microdomains
in Cardiovascular Disorders.
Adv Exp Med Biol. 2017;982:247-264. doi:
10.1007/978-3-319-55330-6_13. Review. PMID: 28551791
Fassina L,
Rozzi G, Rossi S, Scacchi S, Galetti M, Lo Muzio FP, Del
Bianco F, Colli Franzone P, Petrilli G, Faggian G, Miragoli
M*.
Cardiac kinematic parameters
computed from video of in situ beating heart. Sci Rep.
2017 Apr 11;7:46143.
Salvarani
N, Maguy A, De Simone SA, Miragoli M, Jousset F, Rohr S.
TGF-β1 (Transforming Growth Factor-β1) Plays a
Pivotal Role in Cardiac Myofibroblast
Arrhythmogenicity. Circ Arrhythm Electrophysiol.
2017 May;10(5):e004567. doi: 10.1161/CIRCEP.116.004567.
PMID: 28500173
2016
F. Rusconi; P. Ceriotti; M. Miragoli, PG Carullo; N Salvarani, M. Rocchetti, E. Di Pasquale, S. Rossi, M. Tessari, S. Caprari, M. Cazade, P. Kunderfranco, J. Chemin, Marie-Louise Bang, F. Polticelli, A. Zaza, G. Faggian, G. Condorelli, D. Catalucci. Peptidomimetic Targeting of Cavβ2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function. Circulation. 2016 Aug 16;134(7):534-46
Mauro VD, Iafisco M, Salvarani N, Vacchiano M, Carullo P, Ramírez-Rodríguez GB, Patrício T, Tampieri A, Miragoli M*, Catalucci D. Bioinspired negatively charged calcium phosphate nanocarriers for cardiac delivery of MicroRNAs. Nanomedicine (Lond). 2016 Mar 16. 2016 Apr;11(8):891-906
M Miragoli*, J.L. Sanchez-Alonso, A.Bhargava, P.T. Wright, M.Sikkel, S.Schobesberger, I. Diakonov, P.Novak, A.Castaldi, P.Cattaneo, A.R. Lyon, M.J. Lab and J.Gorelik*. Microtubule-dependent mitochondria alignment regulates calcium release in response to nanomechanical stimulus in heart myocytes. Cell Reports. 2016. pii: S2211-1247(15)01427-8
2015-2010
Climent-Salarich M, Quintavalle M., Miragoli M, Chen J., Elia L., Condorelli G. TGFβ triggers miR-143/145 transfer from smooth muscle cells to endothelial cells, thereby modulating vessel stabilization. Circ. Res. 2015 May 22;116(11):1753-64
Savi M., Rossi S., Bocchi L., Genaccaro L., Cacciani F., Perotti A., Amidani D., Alinovi R., Goldoni M., Aliatis I, Lottici P., Bersani D., Campanini M., Pinelli S., Petyx M., Frati C., Gervasi A., Urbanek K, Quaini F.,Buschini A., Stilli D., Rivetti C., Macchi E., Mutti A., Miragoli M*. and Zaniboni M.Titanium Dioxide Nanoparticles Promote Arrhythmias via a Direct Interaction with Rat Cardiac Tissue. Particle and Fibre Toxicology, 2014 Dec 9;11(1):63
Miragoli M, Yacoub MH, El-Hamamsy I, Sanchez-Alonso JL, Moshkov A, Mongkoldhumrongkul N, Padala M, Paramagurunathan S, Sarathchandra P, Korchev YE, Gorelik J, Chester AH. Side Specific Mechanical Properties of Valve Endothelial Cells. Am J Physiol Heart Circ Physiol. 2014 May 2. 2014 Jul 1;307(1):H15-24
Novak P, Shevchuk A, Ruenraroengsak P, Miragoli M, Thorley A.J., Klenerman D, Lab M.J., Tetley T, Gorelik, J, Korchev Y. Imaging single nanoparticle interactions with human lung cells using fast ion conductance microscopy. Nano Lett. 2014 Mar 12;14(3):1202-7. doi: 10.1021/nl404068p. Epub 2014 Feb 24
M.Miragoli*, P.Novak, P.Ruenraroengsak, A.I.Shevchuk, Y.E. Korchev, M,J. Lab, T.D. Tetley and J.Gorelik. Functional Interaction between Charged Nanoparticles and Cardiac Tissue: a New Paradigm for Cardiac Arrhythmia?. Nanomedicine UK. 2013 May;8(5):725-37
Miragoli M, Kadir SH, Sheppard MN, Salvarani N, Virta M, Wells S, Lab MJ, Nikolaev VO, Moshkov A, Hague WM, Rohr S, Williamson C, Gorelik J. A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart. Hepatology. 2011 Oct;54(4):1282-92
V.O. Nikolaev,
A.Moshkov, A.R. Lyon, M.Miragoli, P.Novak, M.J. Lohse, Y.E.
Korchev, S.E. Harding, J.Gorelik. Redistribution of β2
adrenergic receptors contributes to changes in cAMP
compartmentation in heart failure. Science 26 March
2010: 1653-1657